The 34-year-old Rwandese referee will be among the 36 set to officiate matches during the global competition in the Gulf nation.
The competition is set to kick off on Sunday with hosts Qatar taking on Ecuador in a Group A opener at Al Bayt Stadium.
Mukansanga believes more African women referees should officiate in the tournament in the near future because the opportunities are there.
“It’s an honour and a privilege because it’s never happened before,” Mukansanga told BBC Sport Africa, adding: “It means you’re going to be the first one and going to open the door for other women, especially in Africa.
“You carry a lot on your shoulders and you need to carry it well, so others can see that the door is open and they can also go through. It means the opportunities are there – and it’s up to us to take them and become productive from them.”